Mike Smith worked in Dublin and Geneva from 1976 to 1980 developing petroleum information systems for Petroconsultants SA. During that time, he was awarded a DPhil for developing microprocessor-based oceanographic instruments at University College Galway. He was appointed lecturer in computer science at Reading University in 1980 and became Head of R&D for ISTEL, the computing company of Rover Group, in 1984.
Mike held several directorial positions in the petroleum industry and management consultancy until 1990 when he was appointed Professor of Health Informatics at Keele University in the departments of Computer Science and of Medicine; he concurrently held the position of Director of Information at North Staffordshire Health Authority. In 1996 he moved to London and held professorial posts at City University, Barts, LSE, and UCL, as well as consultancy positions at Z/Yen and PwC. In 2000, he founded Medix UK Group plc, creating the largest online community of registered medical professionals, over 35,000 in the UK alone. His next venture was founding fm2x in 2007 and retiring from active academic life in 2008. fm2x provides much of Z/Yen's survey and distributed ledger technologies. Mike is personally involved mainly in the development of large-scale web-based clinical information systems, distributed ledgers, and blockchains.